I introduced Rejuran into my practice in 2024 after it was TGA approved for use in Australia. Up until that time, I believed I did not have a product that I could recommend to my patients that was safe for use in the under-eye area. Biostimulation was a relatively new thing and the products available, in my opinion, were contraindicated in the under eye area due to potential long-term swelling and risk of vascular occlusion (VO). So when Rejuran came along, without a strand of hyaluronic acid to be found, I was excited! Finally a safe product that claimed to address one of the most common concerns patients come to me with - “Help me make tired eyes look fresh again”.

It helped that the industry could promote it online, as it wasn’t classified as a prescription medication. It didn’t hurt that a Kardashian was talking about her “salmon-sperm facial” - that caused some interesting comments during consults! I have now performed hundreds of these treatments, and have seen great results. I’ve had no complications other than some mild bruising, and patients love the results.

When people first hear about Rejuran, one of the most common questions they ask is straightforward: “What does it actually do?” The answer is slightly more nuanced than many cosmetic treatment trends online might suggest. Let’s do a deep dive on Rejuran, PDRN and biostimulation.

The Growing Focus on Natural-Looking Rejuvenation

Modern aesthetic medicine is increasingly moving toward treatments that support overall skin quality and subtle rejuvenation rather than dramatic alteration. This broader trend reflects changing patient priorities. For many individuals, the goal is no longer to look significantly different. Instead, it is to maintain skin quality, support healthier-looking skin, and age in a more gradual and balanced way.

That shift has become one of the defining themes of contemporary aesthetic medicine.

I’m going to delve into some scientific research now and it’s technical, but I think it’s important. There are a lot of people out there selling you “medical aesthetics” and “evidence-based” treatments. This is the evidence.

What Is Rejuran?

Rejuran is a treatment based on polynucleotides, commonly referred to as PDRN (polydeoxyribonucleotide). Where do the PDRN come from? Yup, salmon DNA. A 95-97% match to human DNA (depending who you ask), derived from salmon sperm. This means that you have a low likelihood of allergic reaction, as most people with a fish allergy are sensitive to the flesh of the fish. Polynucleotides have been studied for their role in tissue repair and regenerative processes.

Did someone say studied? Let’s look at some studies!

“Effects of Polydeoxyribonucleotide in the Treatment of Pressure Ulcers” Published in the Journal of Korean Medical Science (2014).

This paper is one of the more clinically relevant human studies investigating PDRN in wound healing. Importantly, it was a randomised controlled trial, performed on humans, but focussed on chronic wound healing, which is ok because it is directly relevant to tissue repair biology, and skin rejuvenation is all about this. That also makes it considerably stronger evidence than many purely cosmetic or laboratory-only discussions surrounding PDRN. The study investigated whether PDRN could improve healing in pressure ulcers (pressure sores).

Sure, not under eye dark circles, but we’re talking about the universal mechanics of cellular repair.

Pressure ulcers are chronic wounds caused by prolonged tissue pressure. These wounds are clinically important because they are difficult to heal, associated with prolonged hospital stay, associated with infection risk and biologically impaired healing environments. I am still work in a public Emergency Department, so I find this relevent.

It was a randomised controlled pilot trial that had 23 participants - 11 in the experimental group, 12 in the control group.
The experimental group received: PDRN injections for 4 weeks. Both groups still received standard pressure wound care - so the study assessed using PDRN in addition to standard care. The researchers used Wound Surface Area and the PUSH Score (Pressure Ulcer Scale for Healing), and found that after 4 weeks, the PDRN group showed a significant reduction in wound size, improvement in PUSH scores indicating improved wound healing progression, and importantly no major adverse effects reported during the study period. The study looked into how PDRN works, so if you don’t mind some more science:-

1. Adenosine A2A Receptor Activation

This signalling pathway has been associated with: angiogenesis tissue repair cell proliferation reduced inflammatory injury. The authors also described PDRN as potentially helping: tissue regeneration re-epithelialisation wound repair .

2. Angiogenesis

The paper references prior studies showing: improved vascularisation improved blood supply to healing tissue This is biologically important because chronic wounds often suffer from impaired perfusion.

Despite looking into wound healing rather than aesthetic applications, this paper is important because:

• it is human clinical data

• it studies impaired wound healing

• it demonstrates measurable clinical endpoints it moves beyond purely theoretical cosmetic claims

This provides a stronger evidence foundation for statements such as:
“PDRN has been studied in wound healing and tissue repair contexts”
than for statements like:
“PDRN reverses ageing” or “PDRN regenerates skin.”

Those latter claims go well beyond the evidence.

“Polydeoxyribonucleotide: A Promising Biological Platform to Accelerate Impaired Skin Wound Healing” by Mariarosaria Galeano et al. Published in Pharmaceuticals (2021).

This paper is valuable because it synthesises:

• molecular biology

• receptor pharmacology

• angiogenesis research

• fibroblast biology

• inflammation pathways

• wound-healing studies, and

• clinical wound-healing trials

into a coherent biological framework. The authors argue that PDRN may assist impaired wound healing through multiple coordinated biological mechanisms. Rather than acting through a single isolated pathway, PDRN is proposed to influence:

• inflammation

• angiogenesis

• fibroblast activity

• tissue oxygenation

• extracellular matrix repair

• cellular proliferation

• regenerative signalling

The paper describes two major biological pathways, similar to the first paper we looked at. They went a step further though, and this next part is more relevant to an aesthetics application.

Effects on Fibroblasts and the Extracellular Matrix.

The review discusses evidence suggesting PDRN may influence fibroblast proliferation, collagen-related signalling, extracellular matrix organisation and tissue remodelling. We talk a lot about the fibroblast in Aesthetics. Fibroblasts are central to collagen synthesis, connective tissue repair, dermal support and wound contraction.

The extracellular matrix (ECM) is also emphasised as critical for tissue structure, hydration, repair coordination and cellular communication. This aligns strongly with current “skin quality” discussions in cosmetic medicine. The paper repeatedly discusses inflammatory modulation. The authors describe evidence suggesting PDRN may reduce pro-inflammatory cytokines, reduce excessive inflammatory signalling, and improve healing conditions within damaged tissue. This is important because excessive or prolonged inflammation can impair normal wound healing.

If you’ve read the Skin Biostimulation section on the Cosmenon website, you’ll know how I feel about repeated energy-device treatments that stimulate collage production by causing a localised injury.

The important takeaway is that no practitioner should be making false claims when it comes to these treatments. The review does NOT prove that:

• PDRN reverses ageing

• PDRN regenerates skin completely

• PDRN guarantees collagen production

• PDRN produces predictable cosmetic rejuvenation

• PDRN repairs DNA damage in humans cosmetically

If you want to read more, here are a few more interesting articles:
Polynucleotides in Aesthetic Medicine: A Review of Current Practices and Perceived Effectiveness ; Pharmacol., 26 April 2017 Sec. Integrative and Regenerative Pharmacology Volume 8 - 2017

Where was I?

Skin Quality vs Volume

One of the biggest shifts occurring in cosmetic medicine is the increasing focus on skin quality - which suits my particular approach to aesthetics perfectly! I was getting tired of seeing over-filled, alienised people, particularly on certain TV shows…

For many years, aesthetic discussions centred heavily around volume replacement and wrinkle reduction. While these treatments still have an important role, patients are becoming increasingly aware that healthy looking skin itself contributes significantly to a refreshed appearance.

Skin quality refers to characteristics such as:

• smoothness

• hydration

• elasticity

• resilience

• light reflection

• texture

• skin thickness

• overall skin health appearance

Why Skin Changes With Age

Skin ageing is a complex biological process involving multiple structural changes occurring simultaneously. One of the most significant changes involves collagen.

Collagen is one of the major structural proteins within the skin and contributes to firmness and resilience.

Over time, collagen production gradually declines due to intrinsic ageing as well as cumulative environmental exposure, particularly ultraviolet (UV) radiation. This process is accompanied by additional changes involving:

• elastin

• hydration

• fibroblast activity

• dermal thickness

• extracellular matrix structure

• repair capacity

Collectively, these changes contribute to:

• thinner skin

• fine lines

• reduced elasticity

• slower recovery

• texture changes

• increased skin fragility

Importantly, these changes can occur even in individuals who are otherwise healthy and well rested. This is a particularly common presentation among patients who want subtle outcomes without an obviously treated appearance.

If we can now say that PDRN has been studied in wound healing and tissue repair, with clinical evidence suggesting potential benefits in selected wound-healing contexts, we should be able to apply that in cosmetic medicine. PDRN-based treatments can be used within skin-quality focused treatment plans, although individual outcomes vary and suitability requires medical assessment.

I’ve written some articles for you to learn more about biostimulation treatments, without a lot of the scientific jargon.

You can also listen to the “Aesthetics Explained” podcast here.

I’d also really enjoy meeting you in clinic to discuss Rejuran and how it may help you achieve your goals. You can make an appointment online here.

FAQs About Rejuran

What does Rejuran do for the skin?

Rejuran is commonly discussed as a skin quality-focused treatment involving polynucleotides (PDRN). It is generally incorporated into treatment plans centred on hydration, texture, and overall skin quality support.

Is Rejuran a filler?

Rejuran is generally considered separately from traditional volumising dermal fillers. It is more commonly associated with skin quality-focused treatment approaches.

What is PDRN?

PDRN stands for polydeoxyribonucleotide, a category of DNA-derived fragments studied in tissue repair and regenerative medicine contexts.

Does Rejuran change facial shape?

Rejuran is not typically discussed as a treatment designed to dramatically alter facial shape or structure.

Why are skin quality treatments becoming more popular?

Many patients are increasingly seeking subtle, natural-looking approaches focused on healthier-looking skin rather than obvious cosmetic change.

Can the under-eye area be assessed during consultation?

Yes. The under-eye area is commonly discussed during cosmetic consultation because multiple anatomical and skin-quality factors can contribute to a tired appearance.

Is consultation important before cosmetic treatment?

Yes. Appropriate consultation allows assessment of anatomy, suitability, risks, alternatives, and realistic treatment planning. At Cosmenon, consultations focus on assessment, anatomy, and longterm skin quality planning. Treatment recommendations are individualised following medical assessment and discussion of suitability, alternatives, and treatment goals.

So when Rejuran came along, without a strand of hyaluronic acid to be found, I was excited! Finally a safe product that claimed to address one of the most common concerns patients come to me with - help me make tired eyes look fresh again.

It helped that the industry could promote it online, as it wasn’t classified as a prescription medication. It didn’t hurt that a Kardashian was talking about her “salmon-sperm facial” - that caused some interesting comments during consults!

I have now performed hundreds of these treatments, and have seen great results. I’ve had no complications other than some mild bruising, and patients love the results.

But when people first hear about Rejuran, one of the most common questions they ask is straightforward:

“What does it actually do?”

The answer is slightly more nuanced than many cosmetic treatment trends online might suggest.

Let’s do a deep dive on Rejuran, PDRN and biostimulation.

What Is Rejuran?

Rejuran is a treatment based on polynucleotides, commonly referred to as PDRN (polydeoxyribonucleotide).

Where do the PDRN come from? Yup, salmon DNA. A 95-97% match to human DNA (depending who you ask), derived from salmon sperm. This means that you have a low likelihood of allergic reaction, as most people with a fish allergy are sensitive to the flesh of the fish.

Polynucleotides have been studied for their role in tissue repair and regenerative processes.

Did someone say studied? Let’s look at some studies!

“Effects of Polydeoxyribonucleotide in the Treatment of Pressure Ulcers”
Published in the Journal of Korean Medical Science (2014).

This paper is one of the more clinically relevant human studies investigating PDRN in wound healing.

Importantly, it was a randomised controlled trial, perfomed on humans, but focussed on chronic wound healing, which is ok because it is directly relevant to tissue repair biology, and skin rejuvenation is all about this.

That also makes it considerably stronger evidence than many purely cosmetic or laboratory-only discussions surrounding PDRN. The study investigated whether PDRN could improve healing in pressure ulcers (pressure sores). Sure, not under eye dark circles, but let’s keep going.

Pressure ulcers are chronic wounds caused by prolonged tissue pressure. These wounds are clinically important because they are difficult to heal, associated with prolonged hospital stay, associated with infection risk and biologically impaired healing environments.

It was a randomised controlled pilot trial that had 23 participants - 11 in the experimental group, 12 in the control group. The experimental group received: PDRN injections for 4 weeks. Both groups still received standard pressure wound care - so the study assessed using PDRN in addition to standard care.

The researchers used Wound Surface Area and the PUSH Score (Pressure Ulcer Scale for Healing), and found that after 4 weeks, the PDRN group showed a significant reduction in wound size, improvement in PUSH scores indicating improved wound healing progression, and importantly no major adverse effects reported during the study period.

The study looked into how PDRN works, so if you don’t mind some more science:-

1. Adenosine A2A Receptor Activation.
This signalling pathway has been associated with:

• angiogenesis

• tissue repair

• cell proliferation

• reduced inflammatory injury

The authors also described PDRN as potentially helping:

• tissue regeneration

• re-epithelialisation

• wound repair

2. Angiogenesis
The paper references prior studies showing:

• improved vascularisation

• improved blood supply to healing tissue

This is biologically important because chronic wounds often suffer from impaired perfusion.

Why This Study Matters

Despite looking into wound healing rather than aesthetic applications, this paper is important because:

• it is human clinical data

• it studies impaired wound healing

• it demonstrates measurable clinical endpoints

• it moves beyond purely theoretical cosmetic claims

This provides a stronger evidence foundation for statements such as: “PDRN has been studied in wound healing and tissue repair contexts” than for statements like: “PDRN reverses ageing” or “PDRN regenerates skin.” Those latter claims go well beyond the evidence.

“Polydeoxyribonucleotide: A Promising Biological Platform to Accelerate Impaired Skin Wound Healing” by Mariarosaria Galeano et al. Published in Pharmaceuticals (2021).

The paper is valuable because it synthesises:

• molecular biology

• receptor pharmacology

• angiogenesis research

• fibroblast biology

• inflammation pathways

• wound-healing studies

• clinical wound-healing trials

into a coherent biological framework. The authors argue that PDRN may assist impaired wound healing through multiple coordinated biological mechanisms. Rather than acting through a single isolated pathway, PDRN is proposed to influence:

• inflammation

• angiogenesis

• fibroblast activity

• tissue oxygenation

• extracellular matrix repair

• cellular proliferation

• regenerative signalling

The paper describes two major biological pathways, similar to the first paper we looked at. They went a step further though, and this next part is more relevant to an aesthetics application.

Effects on Fibroblasts and Extracellular Matrix

The review discusses evidence suggesting PDRN may influence fibroblast proliferation, collagen-related signalling, extracellular matrix organisation and tissue remodelling.

We talk a lot about the fibroblast in Aesthetics. Fibroblasts are central to collagen synthesis, connective tissue repair, dermal support and wound contraction.

The extracellular matrix (ECM) is also emphasised as critical for tissue structure, hydration, repair coordination and cellular communication

This aligns strongly with current “skin quality” discussions in cosmetic medicine.

The paper repeatedly discusses inflammatory modulation. The authors describe evidence suggesting PDRN may reduce pro-inflammatory cytokines, reduce excessive inflammatory signalling, and improve healing conditions within damaged tissue.

This is important because excessive or prolonged inflammation can impair normal wound healing.

If you’ve read the Skin Biostimulation section on the Cosmenon website, you’ll know how I feel about repeated energy-device treatments that stimulate collage production by causing a localised injury.

Importantly, no practitioner should making false claims when it comes to these treatments. The review does NOT prove that:

• PDRN reverses ageing

• PDRN regenerates skin completely

• PDRN guarantees collagen production

• PDRN produces predictable cosmetic rejuvenation

• PDRN repairs DNA damage in humans cosmetically

If you want to read more, here are a few more interesting articles:

Polynucleotides in Aesthetic Medicine: A Review of Current Practices and Perceived Effectiveness

Pharmacol., 26 April 2017 Sec. Integrative and Regenerative Pharmacology Volume 8 - 2017

Where was I?

Skin Quality vs Volume

One of the biggest shifts occurring in cosmetic medicine is the increasing focus on skin quality - which suits my particular approach to aesthetics perfectly! I was getting tired of seeing over-filled, alienised people, particularly on certain TV shows…

For many years, aesthetic discussions centred heavily around volume replacement and wrinkle reduction. While these treatments still have an important role, patients are becoming increasingly aware that healthy-looking skin itself contributes significantly to a refreshed appearance.

Skin quality refers to characteristics such as:

• smoothness

• hydration

• elasticity

• resilience

• light reflection

• texture

• skin thickness

• overall skin health appearance

Why Skin Changes With Age

Skin ageing is a complex biological process involving multiple structural changes occurring simultaneously.

One of the most significant changes involves collagen.

Collagen is one of the major structural proteins within the skin and contributes to firmness and resilience. Over time, collagen production gradually declines due to intrinsic ageing as well as cumulative environmental exposure, particularly ultraviolet (UV) radiation.

This process is accompanied by additional changes involving:

• elastin

• hydration

• fibroblast activity

• dermal thickness

• extracellular matrix structure

• repair capacity

Collectively, these changes contribute to:

• thinner skin

• fine lines

• reduced elasticity

• slower recovery

• texture changes

• increased skin fragility

Importantly, these changes can occur even in individuals who are otherwise healthy and well rested. This is a particularly common presentation among patients who want subtle outcomes without an obviously treated appearance.

If we can now say that PDRN has been studied in wound healing and tissue repair, with clinical evidence suggesting potential benefits in selected wound-healing contexts, we should be able to apply that in cosmetic medicine. PDRN-based treatments can be used within skin-quality focused treatment plans, although individual outcomes vary and suitability requires medical assessment.

The Growing Focus on Natural-Looking Rejuvenation

Modern aesthetic medicine is increasingly moving toward treatments that support overall skin quality and subtle rejuvenation rather than dramatic alteration. This broader trend reflects changing patient priorities. For many individuals, the goal is no longer to look significantly different. Instead, it is to maintain skin quality, support healthier-looking skin, and age in a more gradual and balanced way.

That shift has become one of the defining themes of contemporary aesthetic medicine.

I’ve written some articles for you to learn more about biostimulation treatments. You can also listen to the “Aesthetics Explained” podcast here.

I’d also really enjoy meeting you in clinic to discuss Rejuran and how it may help you achieve your goals. You can make an appointment online here.

FAQs About Rejuran

What does Rejuran do for the skin?

Rejuran is commonly discussed as a skin quality-focused treatment involving polynucleotides (PDRN). It is generally incorporated into treatment plans centred on hydration, texture, and overall skin quality support.

Is Rejuran a filler?

Rejuran is generally considered separately from traditional volumising dermal fillers. It is more commonly associated with skin quality-focused treatment approaches.

What is PDRN?

PDRN stands for polydeoxyribonucleotide, a category of DNA-derived fragments studied in tissue repair and regenerative medicine contexts.

Does Rejuran change facial shape?

Rejuran is not typically discussed as a treatment designed to dramatically alter facial shape or structure.

Why are skin quality treatments becoming more popular?

Many patients are increasingly seeking subtle, natural-looking approaches focused on healthier-looking skin rather than obvious cosmetic change.

Can the under-eye area be assessed during consultation?

Yes. The under-eye area is commonly discussed during cosmetic consultation because multiple anatomical and skin-quality factors can contribute to a tired appearance.

Is consultation important before cosmetic treatment?

Yes. Appropriate consultation allows assessment of anatomy, suitability, risks, alternatives, and realistic treatment planning.

At Cosmenon, consultations focus on assessment, anatomy, and long-term skin quality planning. Treatment recommendations are individualised following medical assessment and discussion of suitability, alternatives, and treatment goals.

Visit cosmenon.com for more information

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Why your medical history shapes everything that follows

The information gathered from your Intake Form directly determines which treatments are available to you, which require modified protocols, and which are ruled out entirely. A patient on warfarin for instance has a meaningfully different risk profile for injectables than someone who isn’t. A patient with a history of autoimmune conditions may need medical clearance before certain procedures can proceed. I’m not asking these questions to fill out a form - every answer informs a clinical decision.

Lifestyle factors matter too. Smoking impairs healing and circulation. Significant sun damage affects skin behaviour during energy-based treatments. Recent dental work raises infection risk for injectable procedures. None of these are disqualifying on their own, but all of them shape the plan.

Discussing goals and managing expectations

Skilled practitioners probe beyond the surface request. When a patient says “I want to look less tired,” that’s a starting point, not a brief. What does success actually look like for that person? What’s driving the concern? How long have they been thinking about it? These questions aren’t conversational filler, they reveal motivations, emotional context, and whether the patient’s expectations align with what’s clinically achievable. I don’t promise results, but I especially don’t want you to invest in a treatment series and be disappointed with your results.

Reputable clinics also screen for signs of body dysmorphic disorder during this phase. Unrealistic expectations and distorted self-perception are clinical contraindications, not just communication challenges. A patient who can’t be satisfied by any realistic outcome shouldn’t receive treatment until those concerns are properly addressed. Getting this alignment right during consultation is precisely what prevents dissatisfaction after treatment. My personal preference is to liaise in writing with your local doctor (GP) and mental health professionals (psychologist, psychiatrist) prior to performing any cosmetic procedure. I want to know that it is safe for you to proceed and, if you encounter problems, you have a team (including myself) to help you immediately.

How Cosmenon physically assesses your face and skin

Once the history and goals discussion is complete, the assessment moves to the physical. This is where we develop a detailed understanding of your specific facial anatomy and skin condition, well beyond what you might see in a mirror.

Facial mapping and structural analysis

Facial mapping involves a systematic examination of your facial proportions, muscle movement patterns, areas of volume loss, skin laxity, bone structure, and natural asymmetries. The goal is to understand how the ageing process has specifically affected your face, because it doesn’t affect everyone the same way. Where one patient may need volume restoration in the mid-face, another’s primary concern might be dynamic lines from muscle activity. The treatment logic is completely different.

This assessment also identifies where treatment carries elevated anatomical risk. Vascular danger zones for injectables, for example, require precise knowledge of the underlying structures. Your assessment is a clinician-led, tactile and visual process, often augmented by imaging or ultrasound tools, that draws on genuine anatomical knowledge to determine what’s achievable and what isn’t.

The safety checks that happen before any plan is approved

Before any treatment plan is finalised, it goes through a non-negotiable safety layer. This is where contraindications are assessed, medication interactions are reviewed, and deferral decisions are made when necessary. I will tell you everything - everything - about the treatment we have chosen. You cannot make an informed decision if you’re not informed.

Medical contraindications that change the plan

Contraindications fall into two categories. Absolute contraindications prohibit treatment entirely: active infections, open wounds, neuromuscular disorders, allergies and uncontrolled autoimmune or connective tissue disorders. Relative contraindications require modified protocols or medical clearance before proceeding, stable autoimmune conditions, uncontrolled hypertension, active eczema, and recent laser or peel treatments are common examples.

Skin-specific factors also affect timing and product selection independently of general eligibility. Active rosacea, severe psoriasis, and dermatitis all influence when treatment can begin and which products are appropriate. I will not override these checks based on patient preference. If a patient is on a contraindicated medication, treatment is deferred. Patient consent doesn’t remove the clinical contraindication.

Medication interactions, timing windows, and deferral decisions

Certain medications demand a pause before treatment proceeds. Anticoagulants increase bruising risk significantly during injectable procedures. Immunosuppressants impair the healing response. Recent antibiotics or dental work raise the infection risk profile for injectables, typically requiring a two-week window before treatment. These aren’t arbitrary rules, they reflect specific, evidence-based risks that I take seriously.

Cosmenon also enforces waiting periods between different treatment modalities. After a chemical peel or laser treatment, a standard two-week window typically applies before injectable procedures are introduced. This prevents interference between modalities and allows proper healing assessment. A deferral isn’t a rejection. It’s the clinic protecting both your safety and the quality of the eventual outcome, and it’s a sign that the assessment process is working as it should.

How clinics decide the right cosmetic treatment plan: selection and sequencing

With the assessment and safety screening complete, the clinical decision-making shifts to which treatments to recommend and in what order. This stage is where how clinics determine the right treatment for each client becomes most visible.

Non-surgical versus surgical: the decision criteria

Several factors guide this decision: the severity of ageing signs, skin elasticity, patient goals, acceptable downtime, and the desired longevity of results. Non-surgical treatments work well for mild to moderate concerns where skin elasticity is good and the patient wants minimal downtime and subtle, refineable outcomes. Injectables, energy-based devices, and skin resurfacing all have well-defined applications within this range.

Where concerns move beyond that scope, including significant skin laxity, excess tissue, or structural changes that injectables cannot meaningfully address, a surgical referral is the appropriate recommendation. I won’t attempt to replicate surgical outcomes with non-surgical tools. In practice, this means that at a doctor-led clinic, the honest answer sometimes involves directing a patient elsewhere entirely. That transparency is a mark of clinical integrity, not a limitation of the service. Based within the Mayfair Specialist Centre, I have direct access to some of the best surgeons in Melbourne for your consideration, making the referral process exceptionally easy.

Combination treatment planning and sequencing logic

When multiple treatments form part of a plan, the order they’re delivered in is clinically significant. Foundational concerns are addressed first. Volume restoration is commonly sequenced before skin texture work, because restoring structure can change how the surface looks and responds, though sequencing ultimately depends on individual clinical judgement and treatment goals. Energy-based treatments are often introduced after injectables have settled, allowing a clearer assessment of what the skin still needs. Cosmenon does not offer these energy-based treatments, but we know the best in the business and will happily recommend them to patients.

A staged approach is standard practice. Non-surgical treatments are trialled first, with each phase assessed before the next is introduced. This allows clinicians to evaluate individual response, adjust the plan accordingly, and avoid combinations that might interfere with each other’s outcomes. The goal isn’t to do more. It’s to do the right things in the right order.

What a credible treatment plan actually looks like

A well-constructed plan isn’t a list of procedures. It’s a documented, evidence-based proposal that you can review, question, and understand fully before committing to anything.

Informed consent: what it should cover

Thorough informed consent covers the specific treatments proposed, expected outcomes, realistic limitations, and known risks and side effects for each procedure. It also addresses the alternatives that were considered and what the management pathway looks like if something goes wrong. Cost transparency is part of this too: treatment fees, maintenance costs, follow-up appointments, and the clear statement that these procedures are not covered by Medicare should all be documented.

Critically, informed consent is a conversation, not a signature page. Under AHPRA guidelines, patients must receive information in a language they understand, with adequate time to reflect before signing. A patient should leave a consultation knowing exactly what was discussed and why each recommendation was made. This process should be documented formally, with every patient receiving a copy of their consent documentation before any treatment proceeds.

Practitioner qualifications and red flags to watch out for

In Australia, patients should verify AHPRA registration, relevant medical qualifications, and documented training in the specific treatments being proposed. For injectable procedures in particular, the question of whether a doctor is performing the treatment directly, or whether it’s being delegated, is clinically relevant. Regulatory guidance and clinical literature consistently identify operator training and experience as significant factors in complication risk.

These are the red flags that signal a plan wasn’t built around you:

• No medical history form completed before the consultation

• No baseline photographs taken

• No discussion of contraindications or medication interactions

• Consent obtained on the same day as treatment without adequate reflection time

• Pressure to book or pay immediately after the consultation

How clinics decide the right cosmetic treatment plan for clients should always come down to individual assessment. A templated approach, where every patient walks out with the same three treatments regardless of their anatomy or history, is not a plan. It’s a menu.

The consultation is where results are actually decided

What a thorough consultation ultimately produces is a documented, individually constructed proposal: the result of medical history review, goal discussion, facial assessment, skin analysis, safety screening, treatment sequencing, and formal informed consent. Each stage informs the next. Skip any of them and the entire plan becomes less reliable.

Use this framework to evaluate any consultation you attend. Ask about the assessment process before you ask about the treatment. Ask what was ruled out and why. Ask how the sequencing was determined. A clinician who can answer those questions clearly is one who built the plan properly.

That’s precisely how I decide the right cosmetic treatment plan for my patients, and it’s the standard Cosmenon holds every consultation to. At Cosmenon, treatment plans are built from the ground up around each patient’s anatomy, health profile, and stated goals. Book a consultation to find out what a treatment plan built around you actually looks like.

The discussion then moves into the technical aspects of anatomical mapping and safety screening, explaining how these processes guide decision-making, identify procedural risks, and determine whether a patient is best suited to non-surgical treatment or requires surgical referral.

A strong emphasis is placed on informed consent and ethical sequencing—how treatments should be staged and prioritised to achieve balanced, natural outcomes rather than short-term or excessive correction.

Ultimately, this episode provides a clear lens for patients to recognise high-quality, doctor-led care: one that prioritises individual assessment, transparency, and clinical judgement over standardised or volume-driven approaches.